Formulation Capabilities

 

Customized Polymer and Targeting Ligand Synthesis for High Barrier Drugs

 

TTY's synthesis laboratory has unique capabilities and depth of experience in biodegradable polymer and phospholipid/peptide ligand synthesis. To support formulation development, we provide:

  • Customized PLA (Polylactic acid) and PLGA (Poly(lactic-co-glycolic acid)) polymers from lab scale development to GMP production:
    • Specific ratio of Lactic Acid/Glycolic Acid
    • Molecular weight from 5,000 to 300,000 Daltons
    • End group modification
    • Customized polymer conformation, such as linear and star polymers
    • Batch size from gram to kilogram scale
  • Our synthesis experts are devoted to phospholipid ligand synthesis and peptide covalent conjugation
  • Synthesis impurity standards for in-house use
  • Impurity identification and preparation of raw materials, intermediates and finished products
  • Preparation of phospholipid and peptide ligands for liposomal drugs
  • API Survey and pre-formulation studies
  • Preparation of reference standards